Some pharmacogenetic aspects of the <i>ABCB1</i> gene in lopinavir / ritonavir concentration variability in children with HIV infection: A pilot study

Polymorphic variants of the multidrug resistance gene (ABCB1 or MDR1) are associated with changes in absorption and transport drugs body. One substrates ABCB1 transporter is an antiretroviral drug from class protease inhibitors, lopinavir. The aim. To research effect polymorphic C1236T C3435T on plasma concentration lopinavir / ritonavir children adolescents living HIV infection. Methods. genotypes were identified 136 infected adolescents; median age – 10 [7–12] years. was measured blood taken during next scheduled appointment as part dispensary observation at Irkutsk Regional AIDS Centre using high performance liquid chromatography. Results. average duration lopinavir/ritonavir use therapy 55 months. Median viral load patients 1 [1–2.03] log copies/ mL; number CD4 + T cells 38.36 %. frequency occurrence 3435T 1236T alleles ~50 In carriers 3435TT genotype, concentrations 2 12 hours after intake 5050.8 [3615.8–5847.7] 2665.5 [216–4896.3] ng/mL, respectively. 1236TT 4913.5 [3355.1–5733.7] 3290.6 [159.1–4972.5] Conclusions. study did not reveal a significant relationship between carriage intake.